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Your Position: Home > CD3 delta

CD3 delta

Brief Information

Name:T cell surface glycoprotein CD3
Target Synonym:CD3 Complex
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:159
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CDD-C52H8 Cynomolgus Cynomolgus CD3 delta Protein, His Tag
CDD-C52H8-structure
CDD-C52H8-sds
CDD-H5224 Human Human CD3 delta Protein, His Tag
CDD-H5224-structure
CDD-H5224-sds
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Synonym Name

CD3D,CD3-DELTA,T3D

Background

CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

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